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PPTDS-SS31-10MG

SS-31 10mg

SS-31 10mg

The synthetic tetrapeptide SS-31 (Elamipretide) belongs to a specific category of molecules designated as mitochondria-targeted antioxidants. It has drawn substantial interest from researchers due to its distinct capacity to cross the cellular membrane and accumulate specifically inside the inner mitochondrial membrane.

Laboratory studies primarily examine its interaction with cardiolipin, which is a crucial phospholipid required for maintaining mitochondrial architecture and energy production. Exclusively for experimental applications and is not cleared for human or veterinary administration, SS-31 serves as a foundational instrument for exploring cellular metabolic processes and pathways related to oxidative stress.

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Current scientific literature highlights potential across several critical areas of cellular biology:

Mitochondrial Bioenergetics: Investigated for its unique ability to selectively bind to cardiolipin in the inner mitochondrial membrane. This interaction is studied for its potential to stabilise cristae structure, optimise the electron transport chain (ETC), and support efficient ATP production.

Oxidative Stress Modulation: Studied in various models of cellular stress to evaluate its role in down-regulating reactive oxygen species (ROS). Because it localises to the inner mitochondrial membrane, research focuses on its potential to address oxidative stress directly at the source rather than systemically.

Cellular Aging & Senescence: Preclinical models examine the peptide's influence on age-related mitochondrial decay, investigating whether maintaining structural integrity of the organelle can mitigate downstream cellular senescence.

Ischemia-Reperfusion Frameworks: Research explores potential cytoprotective effects in tissue models subjected to oxygen deprivation and subsequent re-oxygenation. This is of particular relevance in cardiac, renal, and neurological research models where mitochondrial vulnerability is high.

Research Insight: By targeting mitochondrial membrane architecture rather than acting as a traditional, non-specific antioxidant, SS-31 offers exciting potential as a targeted tool for exploring mitochondrial preservation and tissue resilience.

Synonyms: MTP-131, Bendavia, D-Arg-Dmt-Lys-Phe-NH2
Molecular Formula: C₃₂H₄₉N₉O₅
Molecular Weight: 639.8 g/mol
CAS Number: 736992-21-5
Sequence: D-Arg-Dmt-Lys-Phe-NH2 (D-Arginine-2,6-dimethyltyrosine-Lysine-Phenylalanine-amide)
Peptide Classification: Mitochondria-targeted antioxidant peptide

Elamipretide (SS-31, Szeto-Schiller-31) is soluble in sterile water and aqueous buffers depending on formulation and purity.

  • Storage and Handling

    Keep vials protected from light and moisture.
    Allow vial and diluent to reach room temperature.
    Reconstitute with Bacteriostatic Water 10 ml.
    Swirl gently.
    After reconstitution: Store at 2-8 °C.
    To minimise freeze–thaw, aliquot according to your protocol and protect from light.
    Use only within research protocols that follow your lab’s Standard Operating Procedure and locall Regulations.

  • Peptides Delivery

    Product image for illustrative purposes only. Please note, vials will arrive unbranded. Vials will be presented with batch numbers, expiry and storage details.

  • Disclaimer

    PPTDS supplies materials strictly for laboratory research. Products are not medications, foods, supplements, or cosmetics. Not for human or veterinary use. By purchasing, you confirm you are a qualified researcher and will handle the material in line with your institution’s policies and applicable laws.